The inheritance of mitochondrial DNA heteroplasmy: random drift, selection or both?
Trends Genet
; 16(11): 500-5, 2000 Nov.
Article
em En
| MEDLINE
| ID: mdl-11074292
ABSTRACT
The mammalian mitochondrial genome (mtDNA) is a small double-stranded DNA molecule that is exclusively transmitted down the maternal line. Pathogenic mtDNA mutations are usually heteroplasmic, with a mixture of mutant and wild-type mtDNA within the same organism. A woman harbouring one of these mutations transmits a variable amount of mutant mtDNA to each offspring. This can result in a healthy child or an infant with a devastating and fatal neurological disorder. Understanding the biological basis of this uncertainty is one of the principal challenges facing scientists and clinicians in the field of mitochondrial genetics.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Seleção Genética
/
DNA Mitocondrial
/
Frequência do Gene
Tipo de estudo:
Clinical_trials
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article