The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate.
Bioorg Med Chem Lett
; 11(7): 895-8, 2001 Apr 09.
Article
em En
| MEDLINE
| ID: mdl-11294386
ABSTRACT
The discovery of a potent intracellular inhibitor of human neutrophil elastase which is orally active and has a long duration of action is described. The pharmacodynamic and pharmacokinetic properties of a trans-lactam development candidate, GW311616A, are described.
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Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Serpinas
/
Lactamas
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article