SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice.
Neurosci Lett
; 306(1-2): 89-92, 2001 Jun 22.
Article
em En
| MEDLINE
| ID: mdl-11403965
ABSTRACT
Mouse models of neurological abnormalities are only valuable if accurately assessed. The three-stage SHIRPA procedure is used for the standardised assessment of mouse phenotype and has been reported in a high throughput experiment in which different mutants were ascertained at one age point using stage 1 of the protocol. In this study we have validated SHIRPA using a large cohort with one single mutation, 'legs at odd angles that causes neurological dysfunction. The cohort aged from 1 to 16 months during this study and this is the first longitudinal SHIRPA analysis.
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Base de dados:
MEDLINE
Assunto principal:
Exame Físico
/
Comportamento Animal
/
Doenças do Sistema Nervoso Central
/
Camundongos Mutantes Neurológicos
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article