OPEC/OJEC for stage 4 neuroblastoma in children over 1 year of age.
Med Pediatr Oncol
; 36(1): 239-42, 2001 Jan.
Article
em En
| MEDLINE
| ID: mdl-11464894
ABSTRACT
BACKGROUND:
This paper reports the toxicity of OPEC/OJEC chemotherapy in stage 4 neuroblastoma patients over 1 year of age. PROCEDURE Ninety-five patients with stage 4 neuroblastoma received alternating courses of OPEC/OJEC--vincristine 1.5 mg/m2 (O), cisplatin 80 mg/m2 (P), etoposide 200 mg/m2 (E), cyclophosphamide 600 mg/m2 (C), and carboplatin 500 mg/m2 (J), every 21 days if there was haematological recovery.RESULTS:
Seventy out of ninety-five (74%) patients completed seven or more courses and were evaluable for toxicity. Of these 70 patients, 33% had more than three episodes of fever and sepsis, 35% required more than five blood or platelet transfusions, 36% had grade 2 or more gastrointestinal toxicity and 9% had neurotoxicity. There was a median reduction in GFR of 32 ml/min/1.73 m2 (-46 to 134) and there was one toxic death.CONCLUSIONS:
OPEC/OJEC is a well-tolerated therapy for stage 4 neuroblastoma over 1 year of age.
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Base de dados:
MEDLINE
Assunto principal:
Doenças da Medula Óssea
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Gastroenteropatias
/
Nefropatias
/
Doenças do Sistema Nervoso
/
Neuroblastoma
Tipo de estudo:
Clinical_trials
/
Incidence_studies
/
Prognostic_studies
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article