Time-dependent effects of phenothiazines on dopamine turnover in psychiatric patients.
Science
; 190(4213): 488-9, 1975 Oct 31.
Article
em En
| MEDLINE
| ID: mdl-1166321
ABSTRACT
Psychiatric patients studied early during treatment with chlorpromazine and thioridazine demonstrated elevated probenecid-induced accumulations of homovanillic acid, a major dopamine metabolite, in cerebrospinal fluid. In those studied after longer periods of treatment with phenothiazines, homovanillic acid values were not elevated. This suggests that there are time-dependent effects of phenothiazines on dopamine turn-over that may be relevant to the time course of antipsychotic efficacy.
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Base de dados:
MEDLINE
Assunto principal:
Tioridazina
/
Encéfalo
/
Dopamina
/
Clorpromazina
Limite:
Humans
Idioma:
En
Ano de publicação:
1975
Tipo de documento:
Article