Ten years of protein kinase B signalling: a hard Akt to follow.
Trends Biochem Sci
; 26(11): 657-64, 2001 Nov.
Article
em En
| MEDLINE
| ID: mdl-11701324
ABSTRACT
It is ten years since the publication of three papers describing the cloning of a new proto-oncogene serine/threonine kinase termed protein kinase B (PKB)/Akt. Key roles for this protein kinase in cellular processes such as glucose metabolism, cell proliferation, apoptosis, transcription and cell migration are now well established. The explosion of publications involving PKB/Akt in the past three years emphasizes the high level of current interest in this signalling molecule. This review focuses on tracing the characterization of this kinase, through the elucidation of its mechanism of regulation, to its role in regulating physiological and pathophysiological processes, to our current understanding of the biology of PKB/Akt, and prospects for the future.
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Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Proteínas Proto-Oncogênicas
/
Proteínas Serina-Treonina Quinases
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article