Hematopoietic stem cell gene therapy.
Int J Hematol
; 75(3): 228-36, 2002 Apr.
Article
em En
| MEDLINE
| ID: mdl-11999349
ABSTRACT
Gene therapy applications that target hematopoietic stem cells (HSCs) offer great potential for the treatment of hematologic disease. Despite this promise, clinical success has been limited by poor rates of gene transfer, poor engraftment of modified cells, and poor levels of gene expression. We describe here the basic approach used for HSC gene therapy, briefly review some of the seminal clinical trials in the field, and describe several recent advances directed toward overcoming these limitations.
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Base de dados:
MEDLINE
Assunto principal:
Terapia Genética
/
Transplante de Células-Tronco Hematopoéticas
/
Doenças Hematológicas
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article