Hypocretin-1 (orexin-A) levels in human lumbar CSF in different age groups: infants to elderly persons.
Sleep
; 25(3): 337-9, 2002 May 01.
Article
em En
| MEDLINE
| ID: mdl-12003164
ABSTRACT
STUDY OBJECTIVES:
Recent CSF and postmortem brain hypocretin measurements in human narcolepsy suggest that hypocretin deficiency is involved in the pathophysiology of the disease. In this study, we measured CSF hypocretin-1 levels in various age ranges from infants to elder people to investigate the age-dependent change of hypocretin concentrations.DESIGN:
CSF hypocretin levels were compared by age groups and gender. ANOVA was used to examine the influences of these two parameters on CSF hypocretin levels.SETTING:
University-based sleep and biology laboratory. PATIENTS ORPARTICIPANTS:
Two hundred seventy two patients were included in this study, with 157 males and 115 females (0-79 years old).INTERVENTIONS:
CSF samples were obtained by lumber punctures with informed consents. MEASUREMENTS ANDRESULTS:
Hypocretin-1 levels are not different in respect to gender or age, although our samples constitute a heterogeneous group with various disease conditions. CSF hypocretin-1 levels in infants under 4 months are similar to those in adults.CONCLUSIONS:
Early maturation of hypocretin transmission is suggested. No age- or gender-dependent changes in CSF hypocretin is observed.
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Base de dados:
MEDLINE
Assunto principal:
Neuropeptídeos
/
Proteínas de Transporte
/
Peptídeos e Proteínas de Sinalização Intracelular
/
Narcolepsia
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Infant
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article