Enhanced tumor formation in mice heterozygous for Blm mutation.
Science
; 297(5589): 2051-3, 2002 Sep 20.
Article
em En
| MEDLINE
| ID: mdl-12242442
ABSTRACT
Persons with the autosomal recessive disorder Bloom syndrome are predisposed to cancers of many types due to loss-of-function mutations in the BLM gene, which encodes a recQ-like helicase. Here we show that mice heterozygous for a targeted null mutation of Blm, the murine homolog of BLM, develop lymphoma earlier than wild-type littermates in response to challenge with murine leukemia virus and develop twice the number of intestinal tumors when crossed with mice carrying a mutation in the Apc tumor suppressor. These observations indicate that Blm is a modifier of tumor formation in the mouse and that Blm haploinsufficiency is associated with tumor predisposition, a finding with important implications for cancer risk in humans.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome de Bloom
/
Linfoma de Células T
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Adenosina Trifosfatases
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DNA Helicases
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Predisposição Genética para Doença
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Heterozigoto
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Neoplasias Intestinais
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article