Auditory comprehension of language in young children: neural networks identified with fMRI.
Neurology
; 60(10): 1598-605, 2003 May 27.
Article
em En
| MEDLINE
| ID: mdl-12771248
ABSTRACT
OBJECTIVE:
The organization of neuronal systems that process language in young children is poorly understood. The authors used fMRI to identify brain regions underlying auditory comprehension in healthy young children.METHODS:
Fifteen right-handed children (mean age 6.8 years) underwent fMRI at 1.5-T using blood oxygen level dependent echoplanar imaging. They listened to stories with a reverse speech control condition. Group data were analyzed with statistical parametric mapping. Individual subject data were analyzed with a region of interest approach based on t-maps. An asymmetry index (AI = [(L-R)/(L+R)]) was calculated for each region.RESULTS:
Group analysis showed significant activation in the left middle temporal gyrus (Brodmann area [BA] 21) and left superior temporal gyrus (BA 22) along the superior temporal sulcus extending back to the angular gyrus (BA 39). Individual maps showed lateralized activation in temporal regions (AI > 0.49 +/- 0.39). There was minimal activation in the frontal lobe. There were no significant correlations between age and regional AI.CONCLUSION:
Networks for auditory language processing are regionally localized and lateralized by age 5. These data may provide a means to interpret language fMRI studies performed in preparation for brain surgery, and may be employed to investigate the effect of chronic disease states, such as epilepsy, on language organization during critical periods for plasticity.
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Base de dados:
MEDLINE
Assunto principal:
Mapeamento Encefálico
/
Imageamento por Ressonância Magnética
/
Desenvolvimento Infantil
/
Compreensão
/
Desenvolvimento da Linguagem
/
Rede Nervosa
Limite:
Child
/
Child, preschool
/
Female
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Humans
/
Male
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article