Immunomodulatory effect of peripheral benzodiazepine receptor ligands on human mononuclear cells.
J Neuroimmunol
; 38(1-2): 19-25, 1992 May.
Article
em En
| MEDLINE
| ID: mdl-1315795
ABSTRACT
Immunomodulatory effect of ligands active at the peripheral benzodiazepine receptor (PBR) was examined in human peripheral blood mononuclear cells (PBMC). Ro5-4864, PK11195 and diazepam suppressed phytohemagglutinin (PHA) and concanavalin A (ConA) induced proliferation of PBMC. All three ligands inhibited interleukin-3-like activity (IL-3-LA) secretion, while the production of interleukin-2 (IL-2) was inhibited by Ro5-4864 and diazepam only. The selective central benzodiazepine ligand clonazepam did not affect the cellular immune functions examined. Our results indicate an in-vitro immuno-suppressive activity of peripheral and mixed, but not central type benzodiazepine ligands.
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Base de dados:
MEDLINE
Assunto principal:
Leucócitos Mononucleares
/
Adjuvantes Imunológicos
/
Receptores de GABA-A
/
Ligantes
Limite:
Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article