The cloning of a family of genes that encode the melanocortin receptors.
Science
; 257(5074): 1248-51, 1992 Aug 28.
Article
em En
| MEDLINE
| ID: mdl-1325670
ABSTRACT
Melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) regulate pigmentation and adrenal cortical function, respectively. These peptides also have a variety of biological activities in other areas, including the brain, the pituitary, and the immune system. A complete understanding of the biological activities of these hormones requires the isolation and characterization of their corresponding receptors. The murine and human MSH receptors (MSH-Rs) and a human ACTH receptor (ACTH-R) were cloned. These receptors define a subfamily of receptors coupled to guanine nucleotide-binding proteins that may include the cannabinoid receptor.
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Base de dados:
MEDLINE
Assunto principal:
Receptores do Hormônio Hipofisário
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article