Modulation of kinin responses in human synovium by interleukin-1.
Agents Actions Suppl
; 38 ( Pt 2): 16-22, 1992.
Article
em En
| MEDLINE
| ID: mdl-1334331
ABSTRACT
Bradykinin (BK) is a weak stimulus for prostaglandin E2 (PGE2) release in untreated human synovial cells, but a potent stimulus in interleukin-1 (IL-1) pretreated cells. The mechanism(s) by which IL-1 induces responsiveness of synovial cells to BK appears to be multifactorial. IL-1 not only upregulates the number of kinin receptors on these cells, but may also upregulate a calcium-dependent process involved in the synthesis of prostaglandins.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Bradicinina
/
Dinoprostona
/
Cálcio
/
Interleucina-1
/
Receptores de Neurotransmissores
Limite:
Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article