Role of testosterone and its metabolites in the differentiation of the mammary gland in rats.
Endocrinology
; 99(6): 1490-5, 1976 Dec.
Article
em En
| MEDLINE
| ID: mdl-137111
ABSTRACT
The capacity of various androgens to virilize the differentiating mammary gland in the female rat fetus has been determined. Testosterone, 5alpha-androstane-3alpha, 17beta-diol (3alpha-diol), and dihydrotestosterone (DHT) virilize the anlagen of the mammary gland by suppressing nipple formation but 5alpha-androstane-3beta, 17beta-diol, androsterone, and dehydroepiandrosterone sulfate do not affect female mammary differentiation. However, unlike the genitalia and wolffian ducts of the female rat fetus in which the masculinizing potency of DHT and 3alpha-diol is greater than that of testosterone, testosterone is more potent than its metabolites DHT and 3alpha-diol, in virilizing the mammary gland. The results suggest that testosterone is the fetal androgen mediating masculine development of the mammary gland.
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Base de dados:
MEDLINE
Assunto principal:
Androgênios
/
Glândulas Mamárias Animais
Limite:
Animals
/
Pregnancy
Idioma:
En
Ano de publicação:
1976
Tipo de documento:
Article