Brain implants in man do not break down the blood-brain barrier to dopamine and domperidone.
Brain Res
; 589(2): E2-4, 1992 Sep 04.
Article
em En
| MEDLINE
| ID: mdl-1393589
ABSTRACT
We have evaluated the blood-brain barrier (BBB) in 8 Parkinsonian patients before and after stereotactic implantation of foetal mesencephalon (STIM) and one patient with an adrenal medullary implant. Parenteral administration of dopamine did not reverse Parkinsonism pre-operatively or at 5 days, 1, 2, 3, 4 months and 1 year post-operatively. Apomorphine and domperidone reversed Parkinsonism and produced dyskinesia in all patients pre- and post-operatively. We conclude that the BBB remains intact to dopamine following implantation.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Barreira Hematoencefálica
/
Dopamina
/
Domperidona
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article