Inhibition of proteases in coagulation, kinin-forming and complement systems by alpha2-plasmin inhibitor.
J Biochem
; 82(4): 969-72, 1977 Oct.
Article
em En
| MEDLINE
| ID: mdl-144728
ABSTRACT
Inhibitory activities of alpha2-plasmin inhibitor against various proteases were investigated. The inhibitor promptly inhibited the esterolytic activity of alpha-chymotrypsin and progressively inhibited the esterolytic or amidolytic activities of bovine plasma kallikrein, bovine thrombin and bovine activated factor X. Heparin had no effect on the reaction of the inhibitor with thrombin or activated factor X. However, the inhibitor had no effect on the activities of human C-1-esterase, papain and snake venom kininogenase. On the basis of its rapid inhibition of kallikrein, alpha2-plasmin inhibitor is considered to exert some regulating effect on kallikrein activity in plasma.
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Base de dados:
MEDLINE
Assunto principal:
Inibidores de Proteases
/
Proteínas Sanguíneas
/
Fibrinolisina
/
Cininas
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1977
Tipo de documento:
Article