Use of the Bayer DCA 2000+ for the measurement of glycated haemoglobin in a remote Australian Aboriginal community.
Ann Clin Biochem
; 40(Pt 5): 566-8, 2003 Sep.
Article
em En
| MEDLINE
| ID: mdl-14503997
BACKGROUND: Good glycaemic control in type 2 diabetes can reduce both morbidity and mortality, and monitoring of glycated haemoglobin A(1c) (HbA(1c)) is currently recommended for this purpose. METHODS: Haemoglobin A(1c) can be measured using the portable Bayer DCA 2000+. As part of a community-based screening project for chronic diseases, subjects with impaired fasting glucose concentrations or diabetes had their HbA(1c) concentration measured on the analyser. HbA(1c) measurements were also made in a laboratory using cation-exchange high-performance liquid chromatography. Results were then compared to those obtained in the field. HbA(1c) values were log(e) transformed to obtain a normal distribution. RESULTS: Mean (95% confidence interval) HbA(1c) measured on the DCA 2000+ (n = 39) was 6.3% (5.8, 6.9%), while that measured in the laboratory was 6.5% (6.0, 7.0%). The correlation coefficient (r) between the measurements was 0.96 (P < 0.01). Bland-Altman analysis revealed that the DCA 2000+ estimate of HbA(1c) could be used interchangeably with that from the laboratory (mean bias = 0.1%, limits of agreement - 1.1, 0.8%). The sensitivity, specificity and positive predictive value of the DCA 2000+ estimate of HbA(1c) using a cut-off value of <7% for adequate glycaemic control, were all 100%. CONCLUSIONS: The DCA 2000+ may be used to measure HbA(1c) in remote communities.
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Base de dados:
MEDLINE
Assunto principal:
Hemoglobinas Glicadas
/
Automonitorização da Glicemia
/
Havaiano Nativo ou Outro Ilhéu do Pacífico
/
Diabetes Mellitus Tipo 2
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Oceania
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article