Long-term behavioural, molecular and morphological effects of neonatal NMDA receptor antagonism.
Eur J Neurosci
; 18(6): 1706-10, 2003 Sep.
Article
em En
| MEDLINE
| ID: mdl-14511349
ABSTRACT
Brief N-methyl-D-aspartate (NMDA) receptor blockade in neonatal rats has been reported to increase neuronal apoptosis. We replicated this finding using MK-801 (0.5 mg/kg) administered twice on postnatal day 7, and then studied the long-term consequences. In adulthood, treated rats showed reduced volume and neuronal number within the hippocampus, and altered hippocampal NMDA receptor (NR1 subunit) expression. Synaptophysin mRNA was decreased in the thalamus (laterodorsal nucleus). Adult MK-801-treated females had prepulse inhibition deficits and increased locomotor activity. The data show that a transient and limited glutamatergic intervention during development can have chronic behavioural, structural and molecular effects. The effects are reminiscent of alterations reported in schizophrenia and, as such, are consistent with hypotheses advocating a role for NMDA receptor hypofunction, and aberrant apoptosis, in the neurodevelopmental pathogenesis of the disorder.
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Base de dados:
MEDLINE
Assunto principal:
Tempo
/
Comportamento Animal
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Maleato de Dizocilpina
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Receptores de N-Metil-D-Aspartato
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Antagonistas de Aminoácidos Excitatórios
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article