Glycan-dependent leukocyte adhesion and recruitment in inflammation.
Curr Opin Cell Biol
; 15(5): 531-8, 2003 Oct.
Article
em En
| MEDLINE
| ID: mdl-14519387
ABSTRACT
Leukocyte recruitment in acute and chronic inflammation is characterized by sequential cell adhesion and activation events. E-, P- and L-selectins mediate initial leukocyte-endothelial-cell adhesion events required for this process. Each selectin recognizes related but distinct counter-receptors displayed by leukocytes and/or the endothelium. These counter-receptors correspond to specific glycoproteins whose 'activity' is enabled by carefully controlled post-translational modifications. Characterization of the glycans associated with E- and P-selectin counter-receptors, and of mice with targeted deletions of glycosyltransferase and sulfotransferase genes, disclose that neutrophil E- and/or P-selectin counter-receptor activities derive, minimally, from essential synthetic collaborations amongst polypeptide N-acetylgalactosaminyltransferase(s), a beta-N-acetylglucosaminyltransferase that assembles core-2-type O-glycans, beta-1,4-galactosyltransferase(s), protein tyrosine sulfotransferase(s), alpha-2,3-sialyltransferases, and a pair of alpha-1,3-fucosyltransferases.
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Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
/
Adesão Celular
/
Selectinas
/
Inflamação
/
Leucócitos
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article