Enhanced menadione cytotoxicity in platelets isolated from streptozotocin-induced diabetic rats.
Thromb Res
; 111(3): 179-83, 2003.
Article
em En
| MEDLINE
| ID: mdl-14678817
ABSTRACT
To study whether chemically induced cytotoxicity occurs in diabetic platelets, platelets isolated from rats made hyperglycemic (diabetic) by a prior intravenous administration of streptozotocin were incubated with menadione and the cytotoxicity was assessed by the amount of lactate dehydrogenase (LDH) released from the menadione exposed platelets as a function of time. Platelets isolated from diabetic rats released greater amount of LDH in response to menadione than those from normal rats. Consistent with this finding, induction of menadione cytotoxicity was not dependent on glutathione depletion, but on greater generation of free radicals in diabetic platelets. Greater sensitivity of diabetic platelets to the menadione-induced cytotoxicity was accompanied by release of serotonin from dense granules, suggesting that this mechanism contributes to cardiovascular diseases in diabetic subjects.
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Base de dados:
MEDLINE
Assunto principal:
Plaquetas
/
Estreptozocina
/
Vitamina K 3
/
Antifibrinolíticos
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article