Correlations between nucleotide frequencies and amino acid composition in 115 bacterial species.
Biochem Biophys Res Commun
; 315(4): 1097-103, 2004 Mar 19.
Article
em En
| MEDLINE
| ID: mdl-14985126
ABSTRACT
We studied the correlations between amino acid composition and mononucleotide and dinucleotide frequencies in 115 bacterial genomes of varying G+C content. Observed amino acid frequencies were compared with those expected from the actual mononucleotide and dinucleotide frequencies. Both mononucleotide and dinucleotide frequencies correlate well with the amino acid frequency, with dinucleotide frequencies doing so better. Despite the strong correlations, some of the observed amino acid frequencies, in particular for Arg, Val, Asp, Glu, Ser, and Cys, were consistently different from predicted values in all genomes. We suggest that this variation from predicted values is a consequence of selection pressure at the level of amino acids, while the close correspondence to the predictions in residues such as Thr, Phe, Lys, and Asn arises only from mutation and selection pressure at the level of the nucleic acid sequences.
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Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
Genes Bacterianos
/
Aminoácidos
/
Nucleotídeos
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article