Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus.
Nat Genet
; 36(7): 683-5, 2004 Jul.
Article
em En
| MEDLINE
| ID: mdl-15220917
ABSTRACT
Kaposi sarcoma is considered a neoplasm of lymphatic endothelium infected with Kaposi sarcoma-associated herpesvirus. It is characterized by the expression of lymphatic lineage-specific genes by Kaposi sarcoma tumor cells. Here we show that infection of differentiated blood vascular endothelial cells with Kaposi sarcoma-associated herpesvirus leads to their lymphatic reprogramming; induction of approximately 70% of the main lymphatic lineage-specific genes, including PROX1, a master regulator of lymphatic development; and downregulation of blood vascular genes.
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Base de dados:
MEDLINE
Assunto principal:
Herpesvirus Humano 8
/
Vasos Linfáticos
/
Endotélio
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article