The -1021C->T DBH gene variant is not associated with epilepsy or antiepileptic drug response.
Neurology
; 63(8): 1497-9, 2004 Oct 26.
Article
em En
| MEDLINE
| ID: mdl-15505174
ABSTRACT
Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine (NE). Animal studies show that genes in the NE pathway are candidates for susceptibility to epilepsy and antiepileptic drug (AED) response. The authors genotyped the -1021C-->T major functional polymorphism in the DBH gene in 675 patients with epilepsy and 1,087 controls. The authors found no association with epilepsy, several epilepsy subtypes, or AED response. The results suggest that the -1021C-->T variant does not contribute to epilepsy.
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Base de dados:
MEDLINE
Assunto principal:
Resistência a Medicamentos
/
Norepinefrina
/
Polimorfismo de Nucleotídeo Único
/
Dopamina beta-Hidroxilase
/
Epilepsia
/
Anticonvulsivantes
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article