Catalytic signal amplification using a Heck reaction. An example in the fluorescence sensing of CuII.
J Am Chem Soc
; 126(45): 14682-3, 2004 Nov 17.
Article
em En
| MEDLINE
| ID: mdl-15535668
ABSTRACT
Catalytic signal enhancement using an organometallic reaction is demonstrated. The reactivity of a Heck cross-coupling reaction that creates a fluorophore is modulated by the addition of a polyazacyclam inhibitor. The inhibitor will complex with Cu(II), which restores the activity of the Pd(II). The addition of Cu(II) therefore leads to the generation of fluorescence, thereby creating a very sensitive assay for Cu(II). The rate of the Heck reaction is followed by monitoring emission as a function of time. The rate is proportional to the Cu(II) concentration and correlates to the affinity of the inhibitor to various metals. This strategy represents a general technique that can be exploited with other catalytic organometallic reactions.
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Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Cobre
/
Compostos Heterocíclicos
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article