Tyrosine kinase inhibitors from the rainforest tree Polyscias murrayi.
Phytochemistry
; 66(4): 481-5, 2005 Feb.
Article
em En
| MEDLINE
| ID: mdl-15694455
ABSTRACT
A series of 3-(4-hydroxyphenyl) propanoic acid derivatives, which inhibit Itk (interleukin-2 inducible T-cell kinase), a Th2-cell target, were isolated from the Australian rainforest tree Polyscias murrayi. The new compound 3-(4-hydroxyphenyl) propionyl choline and a 21 mixture of the new compounds 3,4-di-O-3-(4-hydroxyphenyl) propionyl-1,5-dihydroxycyclohexanecarboxylic acid and 3,5-di-O-3-(4-hydroxyphenyl) propionyl-1,4-dihydroxycyclohexanecarboxylic acid were isolated along with two known compounds 3-(4-hydroxyphenyl) propanoic acid and 3-(3,4-hydroxyphenyl) propanoic acid. Their structures were determined by 1D and 2D NMR spectroscopy. The assay results suggest that both the 3-(4-hydroxyphenyl) propanoate and carboxyl moieties contribute to Itk activity of the compounds.
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Base de dados:
MEDLINE
Assunto principal:
Árvores
/
Proteínas Tirosina Quinases
/
Araliaceae
/
Inibidores de Proteínas Quinases
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article