Protein complexes: structure prediction challenges for the 21st century.
Curr Opin Struct Biol
; 15(1): 15-22, 2005 Feb.
Article
em En
| MEDLINE
| ID: mdl-15718128
ABSTRACT
Only a tiny fraction of the many hundreds of known protein complexes are also of known three-dimensional structure. The experimental difficulties surrounding structure determination of complexes make methods that are able to predict structures paramount. The challenge of predicting complex structures is daunting and raises many issues that need to be addressed. To produce the best models, new prediction methods have to somehow combine partial structures with a mixed bag of experimental data, including interactions and low-resolution electron microscopy images.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Modelos Moleculares
/
Análise de Sequência de Proteína
/
Cristalografia
/
Mapeamento de Interação de Proteínas
/
Modelos Químicos
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article