Detection of subtle reciprocal translocations by fluorescence in situ hybridization.
Clin Genet
; 41(4): 169-74, 1992 Apr.
Article
em En
| MEDLINE
| ID: mdl-1576752
ABSTRACT
Three different subtle reciprocal translocations were detected on long, well-banded chromosomes. The same translocations were examined using fluorescence in situ hybridization (FISH) with chromosome-specific libraries and unique DNA sequences. Our findings show that FISH allows rapid and unequivocal detection and characterization of this type of chromosome rearrangement. This approach is especially useful for prenatal diagnosis when one of the parents is a balanced carrier of such small fragment translocations.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Translocação Genética
/
Hibridização de Ácido Nucleico
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Pregnancy
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article