Expression of endogenous murine leukemia viruses during the course of a protracted immunological disorder.
J Exp Med
; 145(4): 1060-5, 1977 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-16072
ABSTRACT
Mice of the low leukemia (BALB/cJ x A/J)F1 hybrid (CAF1) strain express B-and N-tropic infectious murine leukemia virus (MuLV) after the age of 6 mo. Initation of a protracted immunological disorder, the graft-versus-host reaction (GVHR), at 7 wk of age, accelerates the induction of both these mouse-tropic endogenous viruses, and preferentially enhances the replication of B-tropic MuLV. The earlier appearance of B-tropic MuLV in a greater proportion of mice and in higher titer is thought to be casually related to the eventual development of lymphoreticular tumors in the GVHR mice, since previous studies have shown that these same tumors can be reproduced by inoculating syngeneic recipients with serially passaged GVHR extracts containing B-tropic MuLV.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vírus da Leucemia Murina
/
Reação Enxerto-Hospedeiro
Limite:
Animals
Idioma:
En
Ano de publicação:
1977
Tipo de documento:
Article