Neuropathology of Alzheimer's disease.
Neuroimaging Clin N Am
; 15(4): 755-65, ix, 2005 Nov.
Article
em En
| MEDLINE
| ID: mdl-16443488
ABSTRACT
In 1907, Alois Alzheimer described the presence of plaques and neurofibrillary tangles in a demented patient. Currently, Alzheimer's disease is known to be the most common cause of dementia in elderly patients. In this article, we summarize the most important neuropathologic features of Alzheimer's disease, including amyloid plaques, neurofibrillary tangles, neuronal loss, synaptic depletion, cerebral amyloid angiopathy, Hirano bodies, and granulovacuolar degeneration. We also review the history and application of Alzheimer's disease diagnostic criteria.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Doença de Alzheimer
Limite:
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article