Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis.
Bioorg Med Chem Lett
; 16(7): 1950-3, 2006 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-16460940
ABSTRACT
RO4396686 is a small molecule KDR, FGFR, and PDGFR inhibitor with good pharmacokinetic properties in rodents. In a mouse corneal neovascularization assay, this compound inhibited VEGF-induced angiogenesis. Tested in a H460a xenograft tumor model this agent effected significant tumor growth inhibition at doses as low as 50mg/kg.
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Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Inibidores da Angiogênese
/
Neoplasias Experimentais
/
Neovascularização Patológica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article