Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors.
Nat Neurosci
; 9(3): 372-80, 2006 Mar.
Article
em En
| MEDLINE
| ID: mdl-16474391
ABSTRACT
Local GABA (gamma-aminobutyric acid) circuits contribute to sensory experience-dependent refinement of neuronal connections in the developing nervous system, but whether GABAergic synapses themselves can be rapidly modified by sensory stimuli is largely unknown. Here we report that repetitive light stimuli or theta burst stimulation (TBS) of the optic nerve in the developing Xenopus retinotectal system induces long-term potentiation (LTP) of glutamatergic inputs but long-term depression (LTD) of GABAergic inputs to the same tectal neuron. The LTD is due to a reduction in presynaptic GABA release and requires activation of presynaptic NMDA (N-methyl-D-aspartate) receptors (NMDARs) and coincident high-level GABAergic activity. Thus, the presynaptic NMDAR may function as a coincidence detector for adjacent glutamatergic and GABAergic activities, leading to coordinated synaptic modification by sensory experience.
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Base de dados:
MEDLINE
Assunto principal:
Retina
/
Colículos Superiores
/
Receptores de N-Metil-D-Aspartato
/
Terminações Pré-Sinápticas
/
Depressão Sináptica de Longo Prazo
/
Ácido gama-Aminobutírico
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article