Generation and characterization of dickkopf3 mutant mice.
Mol Cell Biol
; 26(6): 2317-26, 2006 Mar.
Article
em En
| MEDLINE
| ID: mdl-16508007
ABSTRACT
dickkopf (dkk) genes encode a small family of secreted Wnt antagonists, except for dkk3, which is divergent and whose function is poorly understood. Here, we describe the generation and characterization of dkk3 mutant mice. dkk3-deficient mice are viable and fertile. Phenotypic analysis shows no major alterations in organ morphology, physiology, and most clinical chemistry parameters. Since Dkk3 was proposed to function as thyroid hormone binding protein, we have analyzed deiodinase activities, as well as thyroid hormone levels. Mutant mice are euthyroid, and the data do not support a relationship of dkk3 with thyroid hormone metabolism. Altered phenotypes in dkk3 mutant mice were observed in the frequency of NK cells, immunoglobulin M, hemoglobin, and hematocrit levels, as well as lung ventilation. Furthermore, dkk3-deficient mice display hyperactivity.
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Base de dados:
MEDLINE
Assunto principal:
Comportamento Animal
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Ventilação Pulmonar
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Peptídeos e Proteínas de Sinalização Intercelular
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Sistema Imunitário
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article