A new player in CNS myelination.
Neuron
; 49(6): 777-8, 2006 Mar 16.
Article
em En
| MEDLINE
| ID: mdl-16543121
ABSTRACT
The formation of the myelin sheath in the CNS is the endpoint of a defined developmental program along which oligodendrocytes progress. However, the molecular signals required for the initiation of myelination are largely unknown. Ishibashi et al. report in this issue of Neuron that ATP released by axons as a result of electrical stimulation serves as an important myelination signal. Surprisingly, they found that ATP does not act directly on oligodendrocytes but rather on astrocytes, causing the release of leukemia inhibitory factor (LIF), which in turns affects promyelinating oligodendrocytes. These findings uncover a novel role for astrocytes in mediating the intricate communication between axons and myelinating glial cells.
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Base de dados:
MEDLINE
Assunto principal:
Sistema Nervoso Central
/
Oligodendroglia
/
Bainha de Mielina
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article