Rapid improvement in cortical neuronal integrity in amyotrophic lateral sclerosis detected by proton magnetic resonance spectroscopic imaging.
J Neurol
; 253(8): 1060-3, 2006 Aug.
Article
em En
| MEDLINE
| ID: mdl-16609809
ABSTRACT
Riluzole prolongs survival in amyotrophic lateral sclerosis. The temporal and spatial profile of its effect on the brain is unknown. We used proton magnetic resonance spectroscopic imaging to evaluate the neuronal response to 1 day of riluzole treatment in motor and non-motor regions of the brain. In 10 patients the N-acetylaspartate/total creatine (NAA/Cr) ratio increased in the precentral gyrus and supplementary motor area, but not in the post-central gyrus or parietal lobe. Improvement in cortical neuronal metabolic function in the motor cortex occurs early with riluzole treatment.
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Base de dados:
MEDLINE
Assunto principal:
Espectroscopia de Ressonância Magnética
/
Córtex Cerebral
/
Fármacos Neuroprotetores
/
Riluzol
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Esclerose Lateral Amiotrófica
/
Regeneração Nervosa
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article