Lack of TP53 and FMS gene mutations in children with myelodysplastic syndrome.
Cancer Genet Cytogenet
; 166(2): 163-5, 2006 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-16631474
ABSTRACT
Myelodysplastic syndromes (MDS) are rare disorders in children. Molecular mechanisms underlying MDS in children are not yet completely understood. Considering the role of FMS and TP53 gene mutations in adult MDS patients, we analyzed mutations of these genes in a cohort of 35 children with MDS. Single-strand conformation polymorphism polymerase chain reaction analysis performed on FMS codon 969 and TP53 exons 5-9 showed no mutations in the analyzed sequences. Our results suggest that molecular mechanisms of MDS evolution in children are different from those in adults.
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Base de dados:
MEDLINE
Assunto principal:
Síndromes Mielodisplásicas
/
Genes fms
/
Genes p53
/
Mutação
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Child, preschool
/
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article