Fibroblast surface antigen produced but not retained by virus-transformed human cells.
J Exp Med
; 142(2): 530-5, 1975 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-167099
ABSTRACT
Normal human fibroblasts contain a cell type-specific glycoprotein antigen (SF) that is known to be slowly shed into the medium and to be present also in human serum. Immunofluorescence with anti-SF antibodies showed that SF antigen has a highly nonrandom fibrillar distribution in surface of normal fibroblasts. Simian virus 40-transformed fibroblasts also produced the SF antigen, as shown by radioimmunoassay or immunodiffusion tests, but it was not retained by the surface of these cells. This creates a major difference between the surfaces of normal and malignant cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Membrana Celular
/
Fibroblastos
/
Antígenos
Limite:
Humans
Idioma:
En
Ano de publicação:
1975
Tipo de documento:
Article