Regulating cellular oxygen sensing by hydroxylation.
Cardiovasc Res
; 71(4): 642-51, 2006 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-16780822
ABSTRACT
Oxygen homeostasis under conditions of limited O2 supply requires hypoxia-dependent gene regulation. The transcription factor complex hypoxia-inducible factor 1 (HIF-1) has been recognized as the master regulator that mediates the adaptational genetic response to ensure restoration of energy supply. This review will focus on the recent advances in understanding the hypoxia-induced cellular response with particular respect to cellular O2 sensing for adequate control of HIF-1 activation.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Transdução de Sinais
/
Hipóxia Celular
/
Regulação da Expressão Gênica
/
Fator 1 Induzível por Hipóxia
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article