Effect of nCPAP therapy on heart rate in patients with obstructive sleep apnoea-hypopnoea.
QJM
; 99(8): 545-53, 2006 Aug.
Article
em En
| MEDLINE
| ID: mdl-16861714
ABSTRACT
BACKGROUND:
Elevated heart rate (HR) is a risk factor for cardiovascular disease. The effects of obstructive sleep apnoea-hypopnoea syndrome (OSAHS) on HR are controversial.AIM:
To investigate the effect of nasal continuous positive airway pressure (nCPAP) therapy on HR in OSAHS patients.METHODS:
Sixty-two OSAHS patients underwent 24-h electrocardiographic recording, both before and 3 or 4 days after instigation of nCPAP.RESULTS:
After nCPAP was started, HR significantly decreased (mean +/- SD 71.8 +/- 10.6 vs. 67.5 +/- 9.4 bpm, p < 0.0001), both in the daytime (0600-2200 h, 76.3 +/- 12.2 vs. 72.2 +/- 10.2 bpm, p < 0.0001) and at night-time (2200-0600 h, 64.5 +/- 9.1 vs. 60.0 +/- 8.9 bpm, p < 0.0001). HR was significantly reduced in both periods in the 44 patients with hypertension and/or diabetes mellitus, but only during the night-time in the 18 with neither condition. Before nCPAP treatment, HR was positively correlated with percentage time of arterial O2 saturation <90% during sleep (p = 0.008) and with the apnoea-hypopnoea index during sleep (p = 0.003). In 15 patients undergoing HR for 2 days before starting nCPAP, the mean HRs for the two periods were similar (p = 0.95).DISCUSSION:
nCPAP therapy appears to decrease HR in OSAHS patients, and may thereby reduce their risk of cardiovascular disease.
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Base de dados:
MEDLINE
Assunto principal:
Apneia Obstrutiva do Sono
/
Pressão Positiva Contínua nas Vias Aéreas
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Frequência Cardíaca
Tipo de estudo:
Etiology_studies
/
Evaluation_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article