The effect of type 2 diabetes on diastolic function.
Med Sci Sports Exerc
; 38(8): 1384-8, 2006 Aug.
Article
em En
| MEDLINE
| ID: mdl-16888449
ABSTRACT
PURPOSE:
This study aimed to determine whether sedentary overweight subjects with type 2 diabetes have impaired diastolic function compared with equally sedentary and overweight nondiabetic subjects.METHODS:
Mitral valve pulsed Doppler echocardiography and tissue Doppler imaging (TDI) were used to assess left ventricular structure and diastolic function in 40- to 60-yr-old sedentary overweight subjects with type 2 diabetes (N = 13) and age- and body mass-matched sedentary nondiabetic subjects (N = 15). Pseudonormal filling was identified using preload reduction and TDI.RESULTS:
Traditional Doppler mitral inflow parameters were not different between groups; however, early diastolic relaxation, as measured by peak early mitral annular velocity (E') and the ratio of E' and peak late mitral annular velocity (E'/A'), was reduced in type 2 diabetic subjects (P < 0.05). The ratio of peak early mitral inflow (E) to E' (E/E'), an estimate of left ventricular filling pressure, was also higher in the type 2 diabetes group (P < 0.05). The proportions of diastolic impairment (69 vs 40%) and pseudonormal filling (39 vs 20%) were not different between groups (P = 0.18).CONCLUSION:
These findings suggest that type 2 diabetes has an effect on diastolic function that is independent of age and body composition.
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Base de dados:
MEDLINE
Assunto principal:
Disfunção Ventricular Esquerda
/
Diabetes Mellitus Tipo 2
/
Diástole
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article