Effect of obesity on clinical presentation and response to treatment in asthma.
J Asthma
; 43(7): 553-8, 2006 Sep.
Article
em En
| MEDLINE
| ID: mdl-16939998
ABSTRACT
Obesity is a risk factor for being diagnosed with asthma, but there is conflicting evidence on whether obesity is a risk factor for lung function abnormalities characteristic of asthma. We studied a cohort of 488 subjects, 47% of whom were obese. Obese and non-obese subjects with asthma had similar airflow limitation and bronchodilator responsiveness, but obese participants had increased sleep disturbance and gastroesophageal reflux disease, higher cytokine levels, and a trend towards increased exacerbations when treated with theophylline. Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people.
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Base de dados:
MEDLINE
Assunto principal:
Quinolinas
/
Asma
/
Teofilina
/
Broncodilatadores
/
Antiasmáticos
/
Acetatos
/
Obesidade
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article