Preventing recurrence of focal segmental glomerulosclerosis following renal transplantation: a case report.
Pediatr Transplant
; 10(8): 962-5, 2006 Dec.
Article
em En
| MEDLINE
| ID: mdl-17096767
ABSTRACT
While the recurrence of FSGS in a primary renal transplant has been well studied, strategies to prevent subsequent recurrence in later transplants, has not been well formulated. This is important considering that one center's experience with adults reported an initial recurrence rate of 57% with reoccurrence of 37% in subsequent transplants. However, renal function was maintained in 62% (1). In pediatrics, data from a single-center reported 100% recurrence of FSGS in the second allograft after an initial recurrence of 52% (2). Two commentaries reviewing such data, one each in adults and pediatrics, suggested that the benefits of living-related donation might not be realized in patients with FSGS because of this frequent recurrence (3, 4). Here, we report a patient who was considered to be at very high risk for post-transplant recurrence of FSGS, because of the established risk factors, who was successfully retransplanted after a course of pretransplant plasmapheresis, followed by post-transplant plasmapheresis and the use of cyclosporine. Eighteen months post-transplant, he has no proteinuria and his serum creatinine is 1.2 mg/dL.
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Base de dados:
MEDLINE
Assunto principal:
Glomerulosclerose Segmentar e Focal
/
Transplante de Rim
Tipo de estudo:
Risk_factors_studies
Limite:
Adolescent
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article