[Conservation of the MC domains in eukaryotic termination factor eRF3].
Genetika
; 43(1): 38-44, 2007 Jan.
Article
em Ru
| MEDLINE
| ID: mdl-17333937
ABSTRACT
Eukaryotic translation termination employs two protein factors, eRF1 and eRF3. Proteins of the eRF3 family each consist of three domains. The N and M domains vary in different species, while the C domains are highly homologous. The MC domains of Homo sapiens eRF3a (hGSPT I), Xenopus laevis eRF3 (XSup35), and Mus musculus eRF3a (mGSPTI) and eRF3b (mGSPT2) were found to compensate for the sup35-21(ts) temperature-sensitive mutation and lethal disruption of the SUP35 gene in yeast Saccharomyces cerevisiae. At the same time, strains containing the MC domains of the eRF3 proteins from different species differed in growth rate and the efficiency of translation termination.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Terminação de Peptídeos
Limite:
Animals
/
Humans
Idioma:
Ru
Ano de publicação:
2007
Tipo de documento:
Article