Peptidergic correction of behavior in adult progeny of albino rats exposed to acute hypoxia during early organogenesis.
Bull Exp Biol Med
; 142(1): 32-4, 2006 Jul.
Article
em En, Ru
| MEDLINE
| ID: mdl-17369896
ABSTRACT
Physical development, spontaneous behavior, and training capacity were evaluated in adult progeny of albino rats exposed to acute hypobaric hypoxia on days 9-10 of gestation, corresponding to the early organogenesis period. Prenatal hypoxia caused delayed behavioral disorders, which were more pronounced in females born from mothers with low resistance to hypoxia. Therapeutic intranasal administration of Pro-Gly-Pro peptide in a dose of 1 mg/kg to rat pups on days 13-15 of life completely prevented the negative consequences of acute prenatal hypoxia in adult females and leveled virtually all negative consequences, except delayed physical development, in males.
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Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Efeitos Tardios da Exposição Pré-Natal
/
Prolina
/
Hipóxia
/
Transtornos Mentais
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Animals
/
Pregnancy
Idioma:
En
/
Ru
Ano de publicação:
2006
Tipo de documento:
Article