Weekly docetaxel with concomitant radiotherapy in patients with inoperable oesophageal cancer.
Clin Transl Oncol
; 9(3): 177-82, 2007 Mar.
Article
em En
| MEDLINE
| ID: mdl-17403629
ABSTRACT
INTRODUCTION:
To evaluate the efficacy and tolerability of weekly docetaxel concurrent with radiotherapy in inoperable oesophageal cancer patients. MATERIAL ANDMETHODS:
Thirty-four oesophageal cancer patients with co-morbid medical conditions, locally advanced tumours (T4) or advanced age (older than 75 years) received docetaxel (20 mg/m2 weekly) plus concurrent radiotherapy (2 Gy daily, to a total dose of 66 Gy). Twenty-two patients (64%) were stage III, 19 of whom had T4 tumours.RESULTS:
Twenty-seven patients (79%) completed the planned chemoradiotherapy treatment. Nine patients (26%) achieved a complete response and 8 (24%) achieved a partial response, for an overall response rate of 50%. Median survival was 6 months, and 1-year survival was 35%. Patients with T4 tumours had significantly shorter survival than other patients 5 months for T4 tumours vs. 11 months for T1-3 (p=0.04). Grade 3-4 oesophagitis occurred in 6 patients (17%). There were two treatment-related deaths due to radiation pneumonitis.CONCLUSIONS:
Docetaxel plus concurrent radiotherapy is active in poor-prognosis oesophageal cancer patients, with a lower incidence of severe oesophagitis than with cisplatin-based chemoradiotherapy regimens. This schedule can be considered, especially in patients with non-T4 tumours who are not candidates for oesophageal resection.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Esofágicas
/
Carcinoma de Células Escamosas
/
Adenocarcinoma
/
Radioterapia de Alta Energia
/
Taxoides
/
Antineoplásicos Fitogênicos
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Aged80
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article