SKY reveals a high frequency of unbalanced translocations involving chromosome 6 in t(12;21)-positive acute lymphoblastic leukemia.
Leuk Res
; 32(1): 39-43, 2008 Jan.
Article
em En
| MEDLINE
| ID: mdl-17418891
ABSTRACT
The G-band cryptic t(12;21)(p13;q22) is the most common chromosomal rearrangement in childhood acute lymphoblastic leukemia (ALL). To investigate the nature of additional chromosomal events in this group of patients spectral karyotyping (SKY) following G-banding analysis was performed in 14 cases. From these cases six showed structural aberrations of chromosome 6, including both simple deletions and unbalanced translocations, and involved both q (n=4) and p (n=3) arms. The results show that rearrangements of 6p are also non-random events t(12;21)-positive ALL. This study illustrates the value of a combined SKY and G-banding approach in identifying novel karyotypic events in childhood ALL.
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Base de dados:
MEDLINE
Assunto principal:
Translocação Genética
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Cromossomos Humanos Par 6
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Cromossomos Humanos Par 12
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Cromossomos Humanos Par 21
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Cariotipagem Espectral
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Leucemia-Linfoma Linfoblástico de Células Precursoras
Limite:
Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article