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Potent bradykinin B1 receptor antagonists: 4-substituted phenyl cyclohexanes.
Su, Dai-Shi; Lim, John L; Markowitz, M Kristine; Wan, Bang-Lin; Murphy, Kathy L; Reiss, Duane R; Harrell, C Meacham; O'Malley, Stacy S; Ransom, Rick W; Chang, Raymond S L; Pettibone, Douglas J; Tang, Cuyue; Prueksaritanont, Thomayant; Freidinger, Roger M; Bock, Mark G.
Afiliação
  • Su DS; Department of Medicinal Chemistry, West Point, PA 19486, USA. daishi_su@merck.com
Bioorg Med Chem Lett ; 17(11): 3006-9, 2007 Jun 01.
Article em En | MEDLINE | ID: mdl-17428657
ABSTRACT
Selective bradykinin (BK) B(1) receptor antagonists have been shown to be antinociceptive in animal models and could be novel therapeutic agents for the treatment of pain and inflammation. Elucidation of the structure-activity relationships of the biphenyl moiety of the lead compound 1 provided a potent new structural class of BK B(1) receptor antagonists.
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Base de dados: MEDLINE Assunto principal: Piridinas / Anti-Inflamatórios não Esteroides / Cicloexanos / Antagonistas de Receptor B1 da Bradicinina / Hidrocarbonetos Fluorados / Analgésicos Limite: Animals / Humans Idioma: En Ano de publicação: 2007 Tipo de documento: Article
Buscar no Google
Imprimir
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PubMed Links

Base de dados: MEDLINE Assunto principal: Piridinas / Anti-Inflamatórios não Esteroides / Cicloexanos / Antagonistas de Receptor B1 da Bradicinina / Hidrocarbonetos Fluorados / Analgésicos Limite: Animals / Humans Idioma: En Ano de publicação: 2007 Tipo de documento: Article