Kinetic analysis of a general model of activation of aspartic proteinase zymogens involving a reversible inhibitor. II. Contribution of the uni- and bimolecular activation routes.
J Enzyme Inhib Med Chem
; 22(2): 157-63, 2007 Apr.
Article
em En
| MEDLINE
| ID: mdl-17518341
ABSTRACT
From the kinetic study carried out in part I of this series (preceding article) an analysis quantifying the relative contribution to the global process of the uni- and bimolecular routes has been carried out. This analysis suggests a way to predict the time course of the relative contribution as well as the effect on this relative weight of the initial zymogen, inhibitor and activating enzyme concentrations.
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Base de dados:
MEDLINE
Assunto principal:
Ácido Aspártico Endopeptidases
/
Inibidores Enzimáticos
/
Precursores Enzimáticos
/
Modelos Químicos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article