In situ generation of palladium nanoparticles: a simple and highly active protocol for oxygen-promoted ligand-free suzuki coupling reaction of aryl chlorides.

ABSTRACT

An oxygen-promoted ligand-free Suzuki coupling reaction catalyzed by in situ generated palladium nanoparticles in PEG-400 under aerobic conditions has been demonstrated. The reaction was highly efficient for coupling aryl chlorides with phenylboronic acid in short times under mild conditions.