[Clinical-experimental bases of the use of antioxidants in the treatment of mechanical jaundice]. / Kliniko-éksperimental'noe obosnovanie primeneniia antioksidantov v lechenii mekhanicheskoi zheltukhi.

ABSTRACT

The results of clinical (200 patients) and experimental (30 dogs) studies reported by the authors show that lipid peroxidation in obstructive jaundice plays an essential role in hepatic functional and morphological abnormalities. Current examination methods were used which confirmed the well-known pathophysiological abnormalities in the body of patients with obstructive jaundice leading to marked hypoxia of hepatocytes and proved that lipid peroxidation is significantly intensified in a liver affected by subhepatic cholestasis. The authors suggest their own conception of the pathophysiological and biochemical shifts in the organism of a patient with obstructive jaundice which are capable of causing stimulation of lipid peroxidation and accumulation of highly toxic products of this process in the body. A scheme of prevention and treatment of hepatic insufficiency is suggested for practical surgery by antioxidants of direct and mediated action which were selected from a series of drugs currently in use.