Effect of chronic administration of ethanol on the regulation of the delta-subunit of GABA(A) receptors in the rat brain.
Brain Res
; 1174: 47-52, 2007 Oct 12.
Article
em En
| MEDLINE
| ID: mdl-17854781
ABSTRACT
In the present study, we investigated the effect of chronic ethanol (CE) administration on the polypeptide levels of the delta-subunit of GABA(A) receptors and [(3)H]muscimol binding to the immunoprecipitated delta-subunit-containing GABA(A) receptor assemblies in the rat brain. CE administration resulted a down-regulation of polypeptide levels of the delta-subunit of GABA(A) receptors in the rat cerebellum and hippocampus, whereas there were no changes in the delta-subunit polypeptide levels in the rat cerebral cortex. Further, CE administration caused a down-regulation of native delta-subunit-containing GABA(A) receptor assemblies in the rat cerebellum as determined by [(3)H]muscimol binding to the immunoprecipitated receptor assemblies. These results indicate that the delta-subunit-containing GABA(A) receptors may play a role in chronic ethanol-induced tolerance and dependence.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Depressores do Sistema Nervoso Central
/
Cerebelo
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Receptores de GABA-A
/
Etanol
/
Alcoolismo
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article